**Slightly out-of-the-money (OTM) options** tend to experience the highest percentage change in premium for a significant move in the underlying asset. This is due to their **high leverage** and **gamma**, which measures the rate of change of delta. **At-the-money (ATM) options** have the highest gamma, but slightly OTM options offer a balance between leverage and the probability of expiring in-the-money. **Deep out-of-the-money (OTM) options** have low premiums and delta, making their percentage change less significant. **Deep in-the-money (ITM) options** behave more like the underlying asset, with lower percentage changes in premium. **Key SEO keywords:** Options trading, option premium, out-of-the-money options, leverage, gamma, delta, in-the-money options, at-the-money options.